A Systems Biology Model Studying the Role of Cholesterol in Alzheimer’s Disease Progression

A Systems Biology Model Studying the Role of Cholesterol in Alzheimer’s Disease Progression

Title : A Systems Biology Model Studying the Role of Cholesterol in Alzheimer's Disease Progression
Authors :
Kyrtsos, C Rose
Baras, John, S.
Conference : 10th IEEE International Workshop on Biomedical Engineering (10thBioEng) pp. 1-7
Date: October 05 - October 07, 2011

A simplified network describing the interactions between the cholesterol and beta amyloid (Aβ) synthesis pathways was generated using information available from literature and the KEGG database. A system of non-linear differential equations was developed and modeled using several different initial conditions. Rate constants were approximated using ratiometric data from the literature, or by fitting parameters to obtain a stable simulation within given biological constraints. Simulations demonstrated the importance of negative feedback control by cholesterol in the regulation of beta-amyloid levels. Additionally, the effect of reduced LRP-1 levels and oscillatory cholesterol generation was studied.

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