Inflammation and Cholesterol: Friend Or Foe in Alzheimer’s Disease

Inflammation and Cholesterol: Friend Or Foe in Alzheimer’s Disease

Title : Inflammation and Cholesterol: Friend Or Foe in Alzheimer's Disease
Authors :
Kyrtsos, C Rose
Baras, John, S.
Conference : SIAM Conference on the Life Sciences 2012
Date: August 07 - August 10, 2012

Alzheimer’s disease (AD) is the most common form of dementia affecting the elderly, leading to debilitating memory loss and significant cognitive decline. The exact mechanism of pathogenesis is not well understood. Here, we present an organ level model that studies the role of cholesterol metabolism and inflammation in the early stages of AD, demonstrating the importance of brain cholesterol on the expression of beta amyloid. The model has been further validated with experimental data.