A systems biology model studying the role of cholesterol in Alzheimer’s disease progression

A systems biology model studying the role of cholesterol in Alzheimer’s disease progression

Title : A systems biology model studying the role of cholesterol in Alzheimer's disease progression
Authors :
Kyrtsos, C Rose
Baras, John, S.
Conference : ACM Conference on Bioinformatics
Date: August 01 - August 03, 2011

A simplified network describing the interactions between the cholesterol and beta amyloid (Aβ) synthesis pathways was generated using information available from literature and the KEGG database.  A system of non-linear differential equations was developed and modeled using several different initial conditions.  Rate constants were approximated using ratio-metric data from the literature, or by fitting parameters to obtain a stable simulation within given biological constraints.  Simulations demonstrated the importance of negative feedback control by cholesterol in the regulation of beta-amyloid levels.  Additionally, the effect of reduced LRP-1 levels and oscillatory cholesterol generation was studied.

Download Full Paper